購(gòu)物車
幫助
021-54845833/15800441009
克隆類型： mouse monoclonal
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Background: |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. |
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Applications: |
ELISA, WB |
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Name of antibody: |
SKP2 |
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Immunogen: |
Fusion protein of human SKP2 |
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Full name: |
S-phase kinase associated protein 2 |
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Synonyms: |
p45; FBL1; FLB1; FBXL1; F-box protein Skp2 |
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SwissProt: |
Q13309 |
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WB Predicted band size: |
48 kDa |
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WB Positive control: |
HEK293 whole cell lysate |
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WB Recommended dilution: |
1000-5000 |
