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    • DDIT4L抗原（重組蛋白）

      規(guī)格：
      價格：￥
      • 品牌 : 通蔚生物
      • 目錄號 : TW16504
      • 應用 : 僅供科研使用
      • 貨期 : 現貨
      • 規(guī)格 ：1mg/100ug
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    中文名稱： DDIT4L抗原（重組蛋白）

    英文名稱： DDIT4L Antigen (Recombinant Protein)

    別     名： REDD2; Rtp801L

    儲     存： 冷凍（-20℃）

    相關類別： 抗原

    概     述

    Full length fusion protein

    技術規(guī)格

    Full name:

    DNA-damage-inducible transcript 4-like

    Synonyms:

    REDD2; Rtp801L

    Swissprot:

    Q96D03

    Gene Accession:

    BC013592

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.