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    • FKBP4抗原（重組蛋白）

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      價格：￥
      • 品牌 : 通蔚生物
      • 目錄號 : TW18645
      • 應用 : 僅供科研使用
      • 貨期 : 現(xiàn)貨
      • 規(guī)格 ：1mg/100ug
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    中文名稱：FKBP4抗原（重組蛋白）

    英文名稱： FKBP4 Antigen (Recombinant Protein)

    別      名： HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase

    儲      存：冷凍（-20℃）

    相關類別： 抗原

    概      述：

    Fusion protein corresponding to a region derived from 263-459 amino acids of human FKBP4


    技術規(guī)格：

    Full name:

    FK506 binding protein 4

    Synonyms:

    HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase

    Swissprot:

    Q02790

    Gene Accession:

    BC001786

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.