購(gòu)物車(chē)
幫助
021-54845833/15800441009
|
Background: |
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). |
|
Applications: |
WB |
|
Name of antibody: |
EGLN1 |
|
Immunogen: |
Fusion protein of human EGLN1 |
|
Full name: |
egl-9 family hypoxia inducible factor 1 |
|
Synonyms: |
HPH2; PHD2; SM20; ECYT3; HALAH; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2 |
|
SwissProt: |
Q9GZT9 |
|
WB Predicted band size: |
46 kDa |
|
WB Positive control: |
OVCAR8, COS7, U2OS, SH-SY5Y and Hela cells |
|
WB Recommended dilution: |
500-2000 |
