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    • CDKN2A 抗原

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      價格：￥
      • 品牌 : 通蔚生物
      • 目錄號 : TW4230
      • 應用 : 僅供科研使用
      • 貨期 : 現(xiàn)貨
      • 規(guī)格 ：1mg
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    中文名稱：CDKN2A 抗原

    英文名稱：CDKN2A Antigen

    相關類別：抗原

    儲    存： 冷凍（-20℃）

    概    述

    Synthetic peptide corresponding to a region derived from 144-156 amino acids of human cyclin-dependent kinase inhibitor 2A

    技術規(guī)格

    Background

    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.

    Gene Accession

    NP_000068

    Swissprot

    P42771

    Synonyms

    ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A

    Full name

    cyclin-dependent kinase inhibitor 2A