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    • ZC3H7A抗原（重組蛋白）

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      • 品牌 : 通蔚生物
      • 目錄號 : TW6622
      • 應用 : 僅供科研使用
      • 貨期 : 現(xiàn)貨
      • 規(guī)格 ：100ug
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    中文名稱：ZC3H7A抗原（重組蛋白）

    英文名稱： ZC3H7A Antigen (Recombinant Protein)

    別     名： ZC3H7; HSPC055; ZC3HDC7

    儲     存： 冷凍（-20℃）

    相關類別：抗原

    概     述

    Fusion protein corresponding to a region derived from 805-971 amino acids of human ZC3H7A

    技術規(guī)格

    Full name:

    zinc finger CCCH-type containing 7A

    Synonyms:

    ZC3H7; HSPC055; ZC3HDC7

    Swissprot:

    Q8IWR0

    Gene Accession:

    BC012575

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    The zinc finger CCCH domain-containing protein 7A (ZC3H7A), also known as ZC3H7, HSPC055 or ZC3HDC7, is a 971 amino acid protein that contains a C3H1-type zinc finger domain, three C3H1-type zinc fingers and three TPR repeats. Belonging to the ZC3H12 family, ZC3H7A localizes to the nucleus. Existing as two alternatively spliced isoforms, ZC3H7A is encoded by a gene located on human chromosome 16p13.13. Chromosome 16 makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.